Current Issue : October-December Volume : 2015 Issue Number : 4 Articles : 6 Articles
SIFI (solvent induced in-situ forming implant) has received remarkable interest in implant technology over last few decades. SIFI offer a number of advantages over solid implant and microspheric depot. SIFI is an amazing invention which forms an implant after coming in contact with the body fluids upon injection and offer other advantages like sustained drug delivery, improved patient compliance, non invasive application, localized drug delivery, reduced side effects, increased drug loading and simple manufacturing process. This review discuss the various components of SIFI formulation, mechanism of in-situ implant formation, various aspects of sterilization, biocompatibility, stability, various patents and pharmaceutical application using SIFI technology. Though the SIFI technology provides a lot of advantages it do suffer from disadvantages like burst effect, toxicity of organic solvent and lack of toxicity data. New polymer combination, solvent, solvent combination, additives are being investigated to address the problems associated with SIFI. But it can be predicted that this technology will gain further significance in the field of implant technology in the coming years....
Oral route of drug administration is the most common and preferred route of administration. Oral dispersible tablets (ODT) are oral solid dosage forms that disintegrate in the oral cavity in easy swallow residue. Linagliptin which is an oral dipeptidyl peptidase (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). Linagliptin which practically shows poor solubility. The project was aimed to enhance the solubility which in turn improves the bioavailability. DESIGN EXPERT version 8.0.7.1 was selected for designing of the present project to make the project economical and statically significant. Superdisintegrants (croscarmellose sodium, sodium starch glycolate and crospovidone) used in different concentrations. Prepared tablets were evaluated for various in-vitro evaluation tests such as weight variation, thickness, wetting time, drug content, in-vitro disintegration time, in-vitro dissolution. The formulations are analyzed for considered response i.e. disintegration, dissolution with the help of DESIGN EXPERT software and the based on the considered responses an optimized formulation was developed. The Optimized Formulation showed in-vitro drug release 99.45% and is the best formulation....
Osmotic drug delivery systems make a major part of the various NDDS available in the market. Oral osmotically controlled release systems have great advantage of being independent of pH, presence of food and physiological factor like GI motility and transient time. Osmotic pump was suited for drug with moderate solubility and not for those giving high solubility. To overcome this problem Oros-push pull osmotic system were made. But the problem with this system was the complexity in the manufacturing technology i.e., the use of laser technology for formation of delivery orifice. Similar problem was encountered in other osmotic systems such as monolithic osmotic tablet systems and sandwiched osmotic tablet systems. Asymmetric membrane capsular system has been successfully used for the osmotic delivery of poorly water-soluble drug. As the release rate of drug through the asymmetric capsules is directly proportional to solubility of the drug, it has become a big problem for drugs with high solubility to be formulated into this type of system. So that we select water insoluble drug for this purpose, Nifedipine as model drug and controlled release was achieved for an extended period of time. Effect of different formulation variables was studied based on 23 factorial designs; namely, level of osmogen, level polymer and level of pore former. Differential scanning calorimetry showed no incompatibility between the drug and the excipient used in the study. Flow property, Drug content, Weight variation and Dissolution studied were carried out. Result show drug release dependent on the osmotic pressure of the dissolution medium....
Drug delivery specifically in the colonic region is desired for treating Inflammatory Bowel Disease (IBD). Drug targeting to colon was done using chitosan coated liposomes; since liposomes accumulate in the inflamed tissue and chitosan proven mucoadhesive helps to improve the residence time in the tissue. Hence liposomes were prepared by film hydration method and formulation was optimised statistically by Box Behnken design. Optimised liposome dispersion was coated with chitosan, freeze dried and subjected to enzyme incubation and mucoadhesion study to find optimum chitosan coating level. The optimised chitosan coated liposomes were filled inside enteric coated capsules for release specifically in colon. Final formulation was tested on induced colonic inflammation in Wistar rats. Accumulation in inflammatory area was tested by Inverted sac method. Myeloperoxidase (MPO) activity and histopathology comparative study was carried out. The particle size of the resultant formulation was found to be 766 nm, with entrapment efficiency of 61.04%. The in-vitro studies of enteric coated capsules showed that drug release occurred after a lag time after 4 hours, which is approximately the time needed for the dosage form to reach the colon. Chitosan coating was confirmed by checking particle size and zeta potential. Ex-vivo studies indicated that drug accumulation in colonic tissue was greater for chitosan coated liposomes as compared to plain drug and non-coated liposomes. Histopathological examination of tissue showed considerable difference in extent of inflammation before and after treatment with liposomal drug as compared to pure drug....
Nitazoxanide is a broad spectrum anti protozoal agent and also used in the treatment of chronic hepatitis B and C. It is moderately absorbed from the stomach, upon absorption it is rapidly hydrolyzed into its active metabolite (tizoxanide). The objective of the present investigation was to develop a sustained release (SR) tablet formulation of nitazoxanide by employing hydrophilic polymers as drug release retardants. The tablets were prepared by wet granulation technique and evaluated for various physico-chemical parameters. Based on data obtained from the in-vitro drug release studies methocel K100M was selected as a release retardant. The formulation containing 5% w/w of the methocel K 100 M as release retardant met with the predetermined specification. The dissolution data also evaluated for the drug release mechanism and kinetics....
Drug delivery has typically focused on optimizing marketed compounds, improving their effectiveness or tolerability and simplifying their administration. Geomatrix technology is a new drug delivery device in the form of a multi-layer tablet proposed for constant drug release and was developed at University of Pavia, Italy. This technology provides customised levels of controlled release of specific drugs. It consists of a hydrophilic matrix core, containing the active ingredient and one or two impermeable or semi-permeable polymeric coatings are applied on the core. The core contains the active ingredient and the combination of barrier layers control the surface area diffusion of the drug out of the core. The combination of layers each with different rates of swelling, gelling and erosion is responsible for the release of drug. It can be applied to a wide range of therapeutic agents. Polymeric materials play an important role in the functioning of these systems. These polymers act as barriers to control drug release. It is a well-established, validated and customisable oral drug delivery platform technology that is currently used in 8 products that are available in over 80 countries. The tablets employing this technology can be easily manufactured using conventional production equipment. This review focuses on the geometric technology that had been developed to provide controlled release of drugs....
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